Drug Class And Mechanism:
Vardenafil is an oral drug that is used to treat impotence (the
inability to attain or maintain a penile erection.). It is a
phosphodiesterase inhibitor that is similar to sildenafil (Viagra).
Penile erection is caused by the engorgement of the penis with blood. This
engorgement occurs when the blood vessels delivering blood to the penis
increase in size and increase the delivery of blood to the penis. At the
same time, the blood vessels carrying blood away from the penis decrease
in size and decrease the removal of blood from the penis. Sexual
stimulation that leads to the engorgement and erection causes the
production and release of nitric oxide in the penis. Nitric oxide then
activates the enzyme, guanylate cyclase to produce cyclic guanosine
monophosphate (cGMP). The cGMP is primarily responsible for increasing and
decreasing the size of the blood vessels carrying blood to and from the
penis, respectively.
Vardenafil prevents an enzyme called phosphodiesterase-5 from
destroying cGMP so that cGMP persists longer. The longer cGMP persists,
the more prolonged the engorgement of the penis.
Vardenafil was approved by the FDA in August, 2003.
Vardenafil Storage:
Vardenafil should be stored at room temperature between 15-30°C
(59-86°F).
Prescribed For:
Vardenafil is used for the treatment of impotence.
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